A prickly situation: Prickle1 function depends on the signaling context
The gene PRICKLE1 is important for human brain function, as mutations in PRCKLE1 are associated with progressive myoclonus epilepsy (PME). Mutations in prickle orthologs could cause seizures in flies, zebrafish and mice, suggesting a conserved role of Prickle protein in seizure from fruit flies to h...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | English |
| Published: |
University of Iowa
2013
|
| Subjects: | |
| Online Access: | https://ir.uiowa.edu/etd/1517 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=5524&context=etd |