The effect of LMNA mutations on the lamin IG-fold structure and muscle gene expression
Mutations in the human LMNA gene encoding A-type lamins cause a collection of diseases termed laminopathies, including several types of muscular dystrophy. Lamins are intermediate filaments, which line the inner membrane of nuclear envelope. Lamins maintain the nuclear shape and regulate gene expres...
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| Format: | Others |
| Language: | English |
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University of Iowa
2012
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| Online Access: | https://ir.uiowa.edu/etd/3383 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=3328&context=etd |