Toward understanding the role of protein context in the polyglutamine disease, SCA3

The polyglutamine diseases are a clinically heterogeneous group of inherited neurodegenerative disorders caused by expansion of polyglutamine-encoding (CAG)n trinucleotide repeats within the disease genes. It is increasingly clear that the amino acid sequences flanking the polyglutamine expansion in...

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Bibliographic Details
Main Author: Harris, Ginny Marie
Other Authors: Paulson, Henry L.
Format: Others
Language:English
Published: University of Iowa 2011
Subjects:
Online Access:https://ir.uiowa.edu/etd/978
https://ir.uiowa.edu/cgi/viewcontent.cgi?article=2363&context=etd