Development of PEGylated polyacridine peptides for in vivo gene delivery of plasmid DNA

Gene therapy provides an opportunity to ameliorate several genetic disorders and treat numerous diseases by using nucleic acid-based materials to modulate gene activity. However, the greatest challenge for successful gene therapy applications remains delivery. Two general approaches are currently un...

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Bibliographic Details
Main Author: Fernandez, Christian Antonio
Other Authors: Rice, Kevin G.
Format: Others
Language:English
Published: University of Iowa 2010
Subjects:
Online Access:https://ir.uiowa.edu/etd/800
https://ir.uiowa.edu/cgi/viewcontent.cgi?article=1985&context=etd