Identification and impact of Topoisomerase II β induced DNA double-strand breaks in Glioblastoma multiforme: NMDA-receptor signaling pathway as target structure
Glioblastoma multiforme (GBM) is a highly lethal and incurable cancer of the central nervous system and current therapies are challenged by GBMs invasive growth and chemo-radioresistance. Ca2+-permeable N-Methyl-D-aspartate receptors (NMDARs) are important for synaptic transmission of excitatory neu...