The shark strikes twice: Generation of Mono- and Bispecific High-Affinity vNAR Antibody Domains via Step-Wise Affinity Maturation
The aim of the work presented herein was the generation of high-affinity shark vNAR domains targeting different disease related antigens. For this, the natural IgNAR V domain repertoire of the bamboo shark (Chiloscyllium plagiosum) was analyzed and in analogy to these findings, a semi-synthetic comp...
| Main Author: | |
|---|---|
| Format: | Others |
| Language: | English en |
| Published: |
2015
|
| Online Access: | https://tuprints.ulb.tu-darmstadt.de/4481/1/Zielonka_PhD_Thesis.pdf Zielonka, Stefan <http://tuprints.ulb.tu-darmstadt.de/view/person/Zielonka=3AStefan=3A=3A.html> (2015): The shark strikes twice: Generation of Mono- and Bispecific High-Affinity vNAR Antibody Domains via Step-Wise Affinity Maturation.Darmstadt, Technische Universität, [Ph.D. Thesis] |
Internet
https://tuprints.ulb.tu-darmstadt.de/4481/1/Zielonka_PhD_Thesis.pdfZielonka, Stefan <http://tuprints.ulb.tu-darmstadt.de/view/person/Zielonka=3AStefan=3A=3A.html> (2015): The shark strikes twice: Generation of Mono- and Bispecific High-Affinity vNAR Antibody Domains via Step-Wise Affinity Maturation.Darmstadt, Technische Universität, [Ph.D. Thesis]