Exploring Key Orientations of Small Molecules to Disrupt Protein-protein Interactions

Exploring Key Orientations of Small Molecules to Disrupt Protein-protein Interactions

Protein-protein interactions (PPIs) are attractive targets because of their therapeutic potential. One approach to design small molecules that can disrupt the PPIs is to use structural information of proteins. With this approach, triazole-based peptidomimetics that mimic beta-turn hot-spot regions...

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Bibliographic Details
Main Author: Ko, Eunhwa
Other Authors: Burgess, Kevin
Format: Others
Language:en_US
Published: 2012
Subjects:
Explores Key Orientation
Universal Peptidomimetics
minimalist mimics
protein-protein interactions
TrkC
targeted drug delivery
triazole-based beta-turn mimics
bivalent mimics
Online Access:http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10961

Internet

http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10961

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