Structural and Functional Studies of Mycothiol Biosynthesis Precursor Enzyme in Mycobacterium tuberculosis

MshA is a glycosyltransferase that synthesizes the precursor of mycothiol, a low-molecular-weight thiol found exclusively in Actinomycetes, including the virulent pathogen Mycobacterium tuberculosis (Mtb). The structure of MshA from Mtb (herein coined as TbMshA) and its complex with uridine diphosp...

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Bibliographic Details
Main Author: Zhu, Wan Wen
Other Authors: Sacchettini, James C.
Format: Others
Language:en_US
Published: 2012
Subjects:
Online Access:http://hdl.handle.net/1969.1/ETD-TAMU-2011-08-9929