A Systems Biology Approach to Develop Models of Signal Transduction Pathways

A Systems Biology Approach to Develop Models of Signal Transduction Pathways

Mathematical models of signal transduction pathways are characterized by a large number of proteins and uncertain parameters, yet only a limited amount of quantitative data is available. The dissertation addresses this problem using two different approaches: the first approach deals with a model sim...

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Bibliographic Details
Main Author: Huang, Zuyi
Other Authors: Hahn, Juergen
Format: Others
Language:en_US
Published: 2011
Subjects:
Green fluorescent protein (GFP) reporter systems
Fluorescent microscopy image analysis
IL-6 signaling pathway
Inverse problem
K-means clustering
Model simplification
Mathematical modeling
Observability analysis
Principal component analysis
Sensitivity analysis
TNF-α signal transduction
Transcription factor profiles
Online Access:http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8328

Internet

http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8328

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