Mechanism of MDA5 Recognition of Short RNA Ligands and Crystal Structure of PepQ

Mechanism of MDA5 Recognition of Short RNA Ligands and Crystal Structure of PepQ

The innate immune pathways that stimulate the expression of cytokines and proapoptotic factors in response to infection are triggered by the activation of the cytosolic receptors retinoic acid-inducible gene I (RIG-I) and melanoma differentiationassociated gene 5 (MDA5). Activation of both receptors...

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Bibliographic Details
Main Author: Watts, Tylan Aubrey
Other Authors: Li, Pingwei
Format: Others
Language:en
Published: 2013
Subjects:
melanoma differentiation-associated gene 5
MDA5
RIG-I-like receptor
RLR
proline peptidase
PepQ
ribonucleic acid
RNA
X-ray crystallography
protein binding
RNA binding
crystal structure
Online Access:http://hdl.handle.net/1969.1/150979

Internet

http://hdl.handle.net/1969.1/150979

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