I. A1,3-Strain Enabled Retention of Chirality During Bis-Cyclization of β-Ketoamides: Asymmetric Synthesis and Bioactivity of Salinosporamide A and Derivatives II. Optimization of an Organic Syntheses: Asymmetric Nucleophile-Catalyzed Aldol- Lactonization of Aldehyde Acids

I. A1,3-Strain Enabled Retention of Chirality During Bis-Cyclization of β-Ketoamides: Asymmetric Synthesis and Bioactivity of Salinosporamide A and Derivatives II. Optimization of an Organic Syntheses: Asymmetric Nucleophile-Catalyzed Aldol- Lactonization of Aldehyde Acids

The potential of human 20S proteasome inhibitors continues to be of interest for anticancer chemotherapy and the recent FDA approval of bortezomib (Velcade) validates the proteasome as a target for cancer chemotherapy. Salinosporamide A, a marine unique bicycle [3.2.0] Beta-lactone-containing natura...

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Bibliographic Details
Main Author: Nguyen, Henry
Other Authors: Romo, Daniel
Format: Others
Published: 2013
Subjects:
A1,3 strain
Online Access:http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-9035
http://hdl.handle.net/1969.1/148462

Internet

http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-9035
http://hdl.handle.net/1969.1/148462

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