A LENTIVIRAL VECTOR CONFERRING COREGULATED, ERYTHROID-SPECIFIC EXPRESSION OF γ-GLOBIN AND shRNA SEQUENCES TO BCL11A FOR THE TREATMENT OF SICKLE CELL DISEASE

A LENTIVIRAL VECTOR CONFERRING COREGULATED, ERYTHROID-SPECIFIC EXPRESSION OF γ-GLOBIN AND shRNA SEQUENCES TO BCL11A FOR THE TREATMENT OF SICKLE CELL DISEASE

Sickle cell disease (SCD) is a severe hemoglobin disorder caused by co-inheritance of a single mutation in the β-globin gene of adult hemoglobin (HbA; α2β2). This alteration leads to the formation of sickle hemoglobin (HbS; α2βS2) and deformed, sickle-shaped red blood cells (RBCs). Sickle RBCs obstr...

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Bibliographic Details
Main Author: Kitowski, Katherine Anne
Format: Others
Published: OpenSIUC 2016
Subjects:
BCL11A
Fetal Hemoglobin
Lentiviral Gene Therapy
shRNA
Sickle Cell Disease
Online Access:https://opensiuc.lib.siu.edu/theses/1995
https://opensiuc.lib.siu.edu/cgi/viewcontent.cgi?article=3009&context=theses

Internet

https://opensiuc.lib.siu.edu/theses/1995
https://opensiuc.lib.siu.edu/cgi/viewcontent.cgi?article=3009&context=theses

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