TISSUE-SPECIFIC ABLATION OF INSULIN RECEPTOR SIGNALING RESULTS IN INFERTILITY IN FEMALE MICE
IGF1 and its receptor IGF1R have been correlated with the proliferation of granulosa cells as well as steroid synthesis. Studies have shown that conditional ablation of Igf1r in granulosa cells leads to follicular arrest at a secondary stage, absence of ovulation and infertility. With a high homolog...
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| Format: | Others |
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OpenSIUC
2020
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| Online Access: | https://opensiuc.lib.siu.edu/dissertations/1833 https://opensiuc.lib.siu.edu/cgi/viewcontent.cgi?article=2837&context=dissertations |