STUDIES ON THE SIZE AND NON-PLANARITY OF AROMATIC STACKING MOIETY ON CONFORMATION SELECTIVITY AND THERMAL STABILIZATION OF G-QUADRUPLEXES

STUDIES ON THE SIZE AND NON-PLANARITY OF AROMATIC STACKING MOIETY ON CONFORMATION SELECTIVITY AND THERMAL STABILIZATION OF G-QUADRUPLEXES

Targeting DNA has the advantage over proteins for cancer remediation because of the fewer copies of the ligands required for the desired therapeutic effect. Traditionally, covalent DNA binders like alkylating agents have been used to induce genetic instability through the formation of DNA lesions an...

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Bibliographic Details
Main Author: Singh, Mandeep
Format: Others
Published: Scholarly Commons 2020
Subjects:
2-CP = 2-Clip-phen
CD = Circular dichroism
FID = Fluorescent intercalator displacement
G4 = G-quadruplex
ITC = Isothermal titration calorimetry
TRAP = Telomeric repeat amplification protocol
Organic chemistry
Pharmaceutical sciences
Chemistry
Medicinal and Pharmaceutical Chemistry
Medicinal-Pharmaceutical Chemistry
Medicine and Health Sciences
Organic Chemistry
Pharmacy and Pharmaceutical Sciences
Physical Sciences and Mathematics
Online Access:https://scholarlycommons.pacific.edu/uop_etds/3725
https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=4724&context=uop_etds

Internet

https://scholarlycommons.pacific.edu/uop_etds/3725
https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=4724&context=uop_etds

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