Investigating the Effect of Rutaecarpine on the Benzo[a]pyrene-Induced DNA Damage in vitro

Investigating the Effect of Rutaecarpine on the Benzo[a]pyrene-Induced DNA Damage in vitro

Benzo[a]pyrene (BaP), is one of the most potent mutagens and carcinogens known. It requires metabolic activation through cytochrome P450 (CYP)1A1 to yield the ultimate carcinogenic metabolite, benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE). BPDE can bind to DNA and form predominantly covalent (+...

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Bibliographic Details
Main Author: Li, You
Format: Others
Published: Scholarly Commons 2019
Subjects:
Pharmaceutical sciences
Pharmacology
Molecular biology
benzo[a]pyrene
chemoprevention
CYP1A1
DNA damage
metabolism
rutaecarpine
Life Sciences
Medicinal and Pharmaceutical Chemistry
Medicine and Health Sciences
Molecular Biology
Pharmacy and Pharmaceutical Sciences
Online Access:https://scholarlycommons.pacific.edu/uop_etds/3643
https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=4639&context=uop_etds

Internet

https://scholarlycommons.pacific.edu/uop_etds/3643
https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=4639&context=uop_etds

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