Development of Novel Phenanthroline and Thiazole Orange Derived G-quadruplex Ligands and Telomerase Inhibitors
The end of the human chromosome is protected by telomeres which contain a special tandem guanine-rich DNA sequence, 5’-TTAGGG. The length of telomeres is shortened during cell replications, and its length limits the replication capacity of cells. Telomerase is over-expressed in 85–90% of cancer cell...
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Scholarly Commons
2018
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| Online Access: | https://scholarlycommons.pacific.edu/uop_etds/3167 https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=4166&context=uop_etds |