Synthesis of AG10 analogs and optimization of TTR ligands for Half-life enhancement (TLHE) of Peptides
The misassembly of soluble proteins into toxic aggregates, including amyloid fibrils, underlies a large number of human degenerative diseases. Cardiac amyloidosis, which is most commonly, caused by aggregation of Immunoglobulin (Ig) light chains or transthyretin (TTR) in the cardiac muscle, represen...
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| Format: | Others |
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Scholarly Commons
2017
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| Online Access: | https://scholarlycommons.pacific.edu/uop_etds/2975 https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=3974&context=uop_etds |