Exploring the time course of brain 5-hydroxytryptamine via mechanism-based pharmacokinetic-pharmacodynamic modeling
Serotonin (5-hydroxytryptamine, 5-HT) has been heavily implicated in the pathophysiology of depression and although its changes in the brain has been well studied using microdialysis, the analysis of its time data is often insufficient as pharmacokinetic (PK) and pharmacodynamic (PD) concepts are of...
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| Format: | Others |
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Scholarly Commons
2006
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| Online Access: | https://scholarlycommons.pacific.edu/uop_etds/2622 https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=3621&context=uop_etds |