Study of DNA damage on DNA G-quadruplexes and biophysical evaluation of the effects of modified bases (lesions) on their conformation and stability
Exposure of DNA to reactive oxygen species (ROS) results in the modified nucleobases (lesions) as well as strand scissions under physiological conditions. Due to its lowest oxidation potential (1.29 eV), guanine is the most easily oxidisable nucleobase. Furthermore, it has been observed that the 5&#...
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| Format: | Others |
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Scholarly Commons
2014
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| Online Access: | https://scholarlycommons.pacific.edu/uop_etds/134 https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=1133&context=uop_etds |