Study of DNA damage on DNA G-quadruplexes and biophysical evaluation of the effects of modified bases (lesions) on their conformation and stability

Study of DNA damage on DNA G-quadruplexes and biophysical evaluation of the effects of modified bases (lesions) on their conformation and stability

Exposure of DNA to reactive oxygen species (ROS) results in the modified nucleobases (lesions) as well as strand scissions under physiological conditions. Due to its lowest oxidation potential (1.29 eV), guanine is the most easily oxidisable nucleobase. Furthermore, it has been observed that the 5&#...

Full description

Bibliographic Details
Main Author: Aggrawal, Manali
Format: Others
Published: Scholarly Commons 2014
Subjects:
Biochemistry
Biophysics
Pure sciences
Biological sciences
Conformation
DNA damage
G-quadruplex DNA
Lesion
Telomerase
Telomere
Chemicals and Drugs
Chemistry
Medical Pharmacology
Medicinal-Pharmaceutical Chemistry
Medicine and Health Sciences
Pharmaceutical Preparations
Pharmacy and Pharmaceutical Sciences
Physical Sciences and Mathematics
Online Access:https://scholarlycommons.pacific.edu/uop_etds/134
https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=1133&context=uop_etds

Internet

https://scholarlycommons.pacific.edu/uop_etds/134
https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=1133&context=uop_etds

Similar Items