The role of 2-oxoglutarate-dependent dioxygenases in epigenetic regulation of cancer

The role of 2-oxoglutarate-dependent dioxygenases in epigenetic regulation of cancer

Abstract 2-oxoglutarate-dependent dioxygenases (2-OGDDs) are an enzyme family that contains many enzymes that modify chromatin in extensive ways. These enzymes include several histone lysine demethylases (KDMs) and TET enzymes that convert methylated cytosine (5-mC) to 5-hydroxymethylcytosine (5-hm...

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Bibliographic Details
Main Author:	Laukka, T. (Tuomas)
Other Authors:	Karppinen, P. (Peppi)
Format:	Doctoral Thesis
Language:	English
Published:	Oulun yliopisto 2018
Subjects:	DNA methylation TET enzymes cancer-associated 2-oxoglutarate analogues cell differentiation epigenetic regulation histone lysine demethylases histone methylation hypoxia DNA:n metylaatio TET-entsyymit epigeneettinen säätely histonidemetylaasit histonien metylaatio hypoksia karsinogeeniset 2-oksoglutaraattianalogit solujen erilaistuminen
Online Access:	http://urn.fi/urn:isbn:9789526220598 http://nbn-resolving.de/urn:isbn:9789526220598

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