The role of 2-oxoglutarate-dependent dioxygenases in epigenetic regulation of cancer

The role of 2-oxoglutarate-dependent dioxygenases in epigenetic regulation of cancer

Abstract 2-oxoglutarate-dependent dioxygenases (2-OGDDs) are an enzyme family that contains many enzymes that modify chromatin in extensive ways. These enzymes include several histone lysine demethylases (KDMs) and TET enzymes that convert methylated cytosine (5-mC) to 5-hydroxymethylcytosine (5-hm...

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Bibliographic Details
Main Author: Laukka, T. (Tuomas)
Other Authors: Karppinen, P. (Peppi)
Format: Doctoral Thesis
Language:English
Published: Oulun yliopisto 2018
Subjects:
DNA methylation
TET enzymes
cancer-associated 2-oxoglutarate analogues
cell differentiation
epigenetic regulation
histone lysine demethylases
histone methylation
hypoxia
DNA:n metylaatio
TET-entsyymit
epigeneettinen säätely
histonidemetylaasit
histonien metylaatio
hypoksia
karsinogeeniset 2-oksoglutaraattianalogit
solujen erilaistuminen
Online Access:http://urn.fi/urn:isbn:9789526220598
http://nbn-resolving.de/urn:isbn:9789526220598

Internet

http://urn.fi/urn:isbn:9789526220598
http://nbn-resolving.de/urn:isbn:9789526220598

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