Transcriptional regulation of the hepatic cytochrome <em>P450 2a5</em> gene

Transcriptional regulation of the hepatic cytochrome <em>P450 2a5</em> gene

Abstract Cytochrome P450 (CYP) enzymes are the major metabolizers of xenobiotics, e.g. drugs, and environmental toxins. Thus, changes in CYP expression have an important impact on drug metabolism and susceptibility to chemical toxicity. In the present study, the transcriptional mechanisms of both...

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Bibliographic Details
Main Author: Arpiainen, S. (Satu)
Format: Doctoral Thesis
Language:English
Published: University of Oulu 2007
Subjects:
CYP2A5
aryl hydrocarbon receptor
aryl hydrocarbon receptor nuclear translocator
cytochrome P450 enzyme system
hepatocyte nuclear factor 4
nuclear factor I
peroxisome proliferator-activated receptor gamma coactivator-1alpha
upstream stimulatory factors
Online Access:http://urn.fi/urn:isbn:9789514285653
http://nbn-resolving.de/urn:isbn:9789514285653

Internet

http://urn.fi/urn:isbn:9789514285653
http://nbn-resolving.de/urn:isbn:9789514285653

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