Genetic causes of mitochondrial complex I deficiency in children

Genetic causes of mitochondrial complex I deficiency in children

Abstract The mitochondrial oxidative phosphorylation system is composed of five multisubunit enzyme complexes. Complex I is the first and largest of these, containing 46 subunits, seven encoded by mitochondrial DNA (mtDNA) and the rest by nuclear DNA. Isolated complex I deficiency is a major cause...

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Bibliographic Details
Main Author:	Hinttala, R. (Reetta)
Format:	Doctoral Thesis
Language:	English
Published:	University of Oulu 2006
Subjects:	DNA mutational analysis NADH dehydrogenase inborn errors of metabolism mitochondria mitochondrial DNA mitochondrial encephalomyopathies oxidative phosphorylation site-directed mutagenesis
Online Access:	http://urn.fi/urn:isbn:9514282884 http://nbn-resolving.de/urn:isbn:9514282884

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