Intracelulární koncentrace metotrexátu a polymorfismy MTHFR: Vztah ke klinické účinnosti a toxicitě metotrexátu u dětí s juvenilní idiopatickou artritidou
Objective: To investigate whether methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and erythrocyte concentration of methotrexate (EMTX) could serve as predictors of methotrexate (MTX) efficacy and toxicity in patients with juvenile idiopathic arthritis (JIA). Methods: Genet...
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| Format: | Doctoral Thesis |
| Language: | English |
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2010
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| Online Access: | http://www.nusl.cz/ntk/nusl-299392 |