The role of integrin a4B7 binding in HIV-1 subtype C pathogenesis in phenotypically variant CD4+ T cell subsets

The integrin α4β7, which mediates the trafficking of T lymphocytes to the gut associated lymphoid tissue (GALT), a site of rapid HIV replication, has been described as an attachment factor for the HIV envelope protein gp120. While differences in binding affinity of early transmitting and chronic gp1...

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Bibliographic Details
Main Author: Richardson, Simone Irene
Format: Others
Language:en
Published: 2014
Subjects:
Online Access:http://hdl.handle.net/10539/15236