The role of the protein tyrosine phosphatase non-receptor type 22 gene polymorphism in disease susceptibility and severity in black South Africans with rheumatoid arthritis
BACKGROUND: The protein tyrosine phosphatase non receptor type 22 (PTPN22) gene inhibits T-cell activation. A functional single nucleotide polymorphism (SNP) Arg620Trp (rs2476601), resulting from a C→T substitution at nucleotide position 1858, is a significant risk factor for rheumatoid arthritis (R...
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| Format: | Others |
| Language: | en |
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2011
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| Online Access: | http://hdl.handle.net/10539/10841 |