Effect of recombinant mouse sclerostin proteins on bone formation in vitro and in a murine model of sclerosteosis
Sclerosteosis is a severe autosomal recessive sclerosing skeletal dysplasia with no available treatment. It is characterised by excessive bone formation and is caused by mutations in the SOST gene that lead to loss of expression of sclerostin, a protein that acts as a negative regulator of bone form...
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| Language: | en |
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University of Pretoria
2021
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| Online Access: | http://hdl.handle.net/2263/82607 |