Compartmentalization, adaptive evolution and therapeutic response of HIV-1 in the gastrointestinal tract (GIT) of African patients infected with Subtype C: implications for the enhancement of therapeutic efficacy

Compartmentalization, adaptive evolution and therapeutic response of HIV-1 in the gastrointestinal tract (GIT) of African patients infected with Subtype C: implications for the enhancement of therapeutic efficacy

Background: Due to its continuous exposure to food antigens and microbes, the gastrointestinal tract (GIT) is in a constant state of low level immune activation and contains an abundance of activated CCR5+CD4+ T lymphocytes, the primary target HIV-1. As a result, the GIT is a site of intense viral r...

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Bibliographic Details
Main Author: Mahasha, Phetole Walter
Other Authors: Cassol, Sharon
Language:en
Published: University of Pretoria 2015
Subjects:
Human immunodeficiency virus-1 (HIV-1)
Gastrointestinal tract
Antiretroviral therapy (ART)
Viral RNA quasispecies
Genetic diversity
UCTD
CD4 reconstitution
Intestine
Africa
Immune activation
Online Access:http://hdl.handle.net/2263/43156
Mahasha, P 2014, Compartmentalization, adaptive evolution and therapeutic response of HIV-1 in the gastrointestinal tract (GIT) of African patients infected with Subtype C: implications for the enhancement of therapeutic efficacy, PhD Thesis, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/43156>

Internet

http://hdl.handle.net/2263/43156
Mahasha, P 2014, Compartmentalization, adaptive evolution and therapeutic response of HIV-1 in the gastrointestinal tract (GIT) of African patients infected with Subtype C: implications for the enhancement of therapeutic efficacy, PhD Thesis, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/43156>

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