Differential anti-cancer signaling exerted by an in silico-designed compound in tumorigenic and non-tumorigenic breast cells
Microtubule-disrupting agents have been studied for decades for their potential anticancer activity and resulted in discovery of an endogenous 17β-estradiol derivative, 2-methoxyestradiol (2ME2). Since 2ME2 possesses low bioavailability, several analogues with improved efficacy was in silico-designe...
| Main Author: | |
|---|---|
| Other Authors: | |
| Language: | en |
| Published: |
University of Pretoria
2014
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/2263/40255 Visagie, M(H 2014, Differential anti-cancer signaling exerted by an in silico-designed compound in tumorigenic and non-tumorigenic breast cells, PhD Thesis, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/40255> |