Targeted inhibition of the Plasmodium falciparum Vitamin B6 producing enzyme Pdx1 and the biochemical and functional consequences thereof

Targeted inhibition of the Plasmodium falciparum Vitamin B6 producing enzyme Pdx1 and the biochemical and functional consequences thereof

Malaria is caused by the parasite Plasmodium falciparum and still plagues many parts of the world. To date, efforts to control the spread of the parasites have been largely ineffective. Due to development of resistance by the parasites to current therapeutics there is an urgent need for new classes...

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Bibliographic Details
Main Author: Reeksting, S.B. (Shaun Bernard)
Other Authors: Birkholtz, Lyn-Marie
Language:Eng
Published: University of Pretoria 2014
Subjects:
Vitamin b6
PLP
Malaria
Pyridoxal 5'-phosphate
Pdx1
Drug design
Plasmodium falciparum
Therapeutics
UCTD
Online Access:http://hdl.handle.net/2263/32965
Reeksting, S.B. 2013, Targeted inhibition of the Plasmodium falciparum Vitamin B6 producing enzyme Pdx1 and the biochemical and functional consequences thereof, PhD thesis, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/32965>

Internet

http://hdl.handle.net/2263/32965
Reeksting, S.B. 2013, Targeted inhibition of the Plasmodium falciparum Vitamin B6 producing enzyme Pdx1 and the biochemical and functional consequences thereof, PhD thesis, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/32965>

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