Differential effects of arachidonic acid and docosahexaenoic acid on cell biology and osteoprotegerin synthesis in osteoblast-like cells

Differential effects of arachidonic acid and docosahexaenoic acid on cell biology and osteoprotegerin synthesis in osteoblast-like cells

The purpose of the study was to elucidate the mechanisms by which polyunsaturated fatty acids (PUFAs) prevent bone loss. MG-63 human osteoblasts and MC3T3-E1 murine osteoblasts were exposed to the n-6 PUFA arachidonic acid (AA) and the n-3 PUFA docosahexaenoic acid (DHA) as well as oestrogen (E2) an...

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Bibliographic Details
Main Author: Coetzee, Magdalena
Other Authors: Prof M C Kruger
Published: 2013
Subjects:
Osteoblasts
Docosahexaenoic acid
Arachidonic acid
Prostaglandin e2
Differentiation
Osteoprotegerin (opg)
Alkaline phosphatase activity
Proliferation
Transdifferentiation
Polyunsaturated fatty acids
Mineralisation
Receptor activator of nuclear factor êb ligand (ra
UCTD
Online Access:http://hdl.handle.net/2263/23039
http://upetd.up.ac.za/thesis/available/etd-03092006-114304/

Internet

http://hdl.handle.net/2263/23039
http://upetd.up.ac.za/thesis/available/etd-03092006-114304/

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