Synthesis, biological evaluation and molecular docking studies of novel indole- and benzofuran-chalcone and benzofuran-quinazoline hybrids as anticancer agents

Synthesis, biological evaluation and molecular docking studies of novel indole- and benzofuran-chalcone and benzofuran-quinazoline hybrids as anticancer agents

Text in English === Specially prepared 2-amino-5-bromo-3-iodoacetophenone and 5-bromo-2-hydroxy-3 iodoacetophenone were subjected to Claisen-Schmidt aldol condensation with benzaldehyde derivatives followed by sequential and/or one-pot palladium catalyzed Sonogashira cross coupling and heteroannula...

Full description

Bibliographic Details
Main Author: Maluleka, Marole Maria
Other Authors: Mphahlele, M.J.
Format: Others
Language:en
Published: 2019
Subjects:
2-amino-5-bromo-3-iodochalcones
2-amino-3-(arylalkynyl)-5-bromochalcones
Indole-chalcones
3-trifluoroacetylindole-chalcones
X-ray crystal structure
Inversion twin crystals
Benzofuran-chalcones
Benzofuran-aminoquinazolines
2,3-dihydrobenzo[b][1,4]thiazepine–benzofurans
2,3-dihydrobenzo[b][1,4]thiazepine–indoles
Cytotoxicity
Apoptosis
Tubulin
EGFR-TK
Molecular docking
DFT
547.592
Benzofuran > Toxicology
Antineoplastic agents > Pharmacology
Carcinogenicity testing
Online Access:http://hdl.handle.net/10500/25821

Internet

http://hdl.handle.net/10500/25821

Similar Items