Molecular and Kinetic Characteristics of wild type and mutant Porphobilinogen deaminase

The purpose of this dissertation was to provide an overview of acute intermittent porphyria, focussing on the structure and function of the enzyme, porphobilinogen deaminase (PBGD), as well as experimentally demonstrating the use of kinetic, structural and thermodynamic approaches to shed light on t...

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Bibliographic Details
Main Author: Pienaar, Elaine
Format: Dissertation
Language:English
Published: Faculty of Health Sciences 2019
Subjects:
Online Access:http://hdl.handle.net/11427/30119