ATP mimics as glutamine synthetase inhibitors : an exploratory synthetic study

ATP mimics as glutamine synthetase inhibitors : an exploratory synthetic study

Using a mechanism-based approach to drug discovery, efforts have been directed towards developing novel ATP mimics that can act as GS inhibitors. The purine-based systems, adenosine, adenine and allopurinol, were identified as possible scaffolds for potential ATP mimics, while various meta-disubstit...

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Bibliographic Details
Main Author: Salisu, Sheriff Tomilola
Format: Others
Language:English
Published: Rhodes University 2008
Subjects:
Glutamine synthetase
Tuberculosis > Treatment
Tuberculosis > Chemotherapy
Adenosine triphosphate
Adenosine triphosphate > Synthesis
Drug development
Online Access:http://hdl.handle.net/10962/d1006715

Internet

http://hdl.handle.net/10962/d1006715

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