Synthesis of novel inhibitors of 1-Deoxy-D-xylulose-5-phosphate reductoisomerase as potential anti-malarial lead compounds

Synthesis of novel inhibitors of 1-Deoxy-D-xylulose-5-phosphate reductoisomerase as potential anti-malarial lead compounds

This research has focused on the development of novel substrate mimics as potential DXR inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), an essential enzyme in the mevalonate-independent pathway for the biosynthesis of isoprenoids in Plasmodium falciparum. DXR mediates the isomer...

Full description

Bibliographic Details
Main Author: Mutorwa, Marius Kudumo
Format: Others
Language:English
Published: Rhodes University 2011
Subjects:
Antimalarials > Development
Plasmodium falciparum
Malaria > Chemotherapy
Drug development
Lead compounds
Phosphonates
Phosphonic acids
Ligands
Online Access:http://hdl.handle.net/10962/d1005037

Internet

http://hdl.handle.net/10962/d1005037

Similar Items