Evaluation of polycyclic amines as modulators of calcium homeostasis in models of neurodegeneration / Young L.

Evaluation of polycyclic amines as modulators of calcium homeostasis in models of neurodegeneration / Young L.

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Compromised calcium homeostasis in the central nervous system (CNS) is implicated as a major contributor in the pathology of neurodegeneration. Dysregulation of Ca2+ homeostasis initiates downstream Ca2+–dependent events that lead to apoptotic and/or necrotic cell death. Increases in the intracellul...

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Bibliographic Details
Main Author: Young, Lois-May
Published: North-West University 2012
Subjects:
Neurodegeneration
Voltage gated calcium channels (VGCC)
L-type calcium channel (LTCC) blockers
Multifunctional drugs
Polycyclic compounds
Pentacycloundecylamines
Triquinylamines
Neurodegenerasie
Spanningsafhanklike kalsiumkanale
L-tipe spanningsafhanklike kalsiumkanale blokkers
Multi-funksionele verbindings
Polisikliese verbindings
Pentasiklo-undekielamiene
Trikwinielamiene
Online Access:http://hdl.handle.net/10394/7591

Internet

http://hdl.handle.net/10394/7591

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