Molecular Basis for p85 Dimerization and Allosteric Ligand Recognition
The phosphatidylinositol-3-kinase α (PI3Kα) is a heterodimeric enzyme that is composed of a p85α regulatory subunit and a p110α catalytic subunit. PI3Kα plays a critical role in cell survival, growth and differentiation, and is the most frequently mutated pathway in human cancers. The PI3Kα pathway...
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| Language: | en |
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2018
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| Online Access: | http://hdl.handle.net/10754/630289 |