Regulation of microRNA activity by translation initiation factors in melanoma

Regulation of microRNA activity by translation initiation factors in melanoma

microRNAs (miRNAs) are small, noncoding RNAs that may regulate more than half of human genes, yet the molecular mechanism of miRNA-mediated repression remains obscure. Using a cell-free assay of miRNA activity, we show that miRNA-targeted mRNAs are enriched for components of the 40S, but not 60S rib...

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Bibliographic Details
Main Author: Yanez, Adrienne Gail
Other Authors: Novina, Carl D
Language:en_US
Published: Harvard University 2014
Subjects:
Molecular biology
Cellular biology
eIF
microRNA
translation
Online Access:http://dissertations.umi.com/gsas.harvard:11578
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274340

Internet

http://dissertations.umi.com/gsas.harvard:11578
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274340

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