Physiological and Pharmacological Regulation of the STAT3 Pathway in Cancer
STAT3 is a critical oncogenic transcription factor, but how it becomes aberrantly activated in cancer is unclear. We have discovered a new pathway whose loss is associated with persistent STAT3 activation in human cancer. We found that the tumor suppressor miR-146b is a direct STAT3 target gene in n...
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| Language: | en_US |
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Harvard University
2013
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| Online Access: | http://dissertations.umi.com/gsas.harvard:11062 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181218 |