Systematic approaches to overcoming limitations of MAPK pathway inhibition in melanoma
Metastatic melanoma is an aggressive, incurable cancer with historically few therapeutic options. The discovery that 60% of melanomas harbor the oncogenic BRAF_V600E mutation, which constitutively activates the MAPK pathway, has provided a promising new therapeutic axis. Although MAPK pathway inhi...
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| Language: | en_US |
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Harvard University
2013
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| Online Access: | http://dissertations.umi.com/gsas.harvard:11094 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11169802 |