CRKL Is an Important Regulator of PI3K Signaling in PTEN-Deficient Tumors
In response to signals mediated by receptor tyrosine kinases (RTKs), G protein-coupled receptors or oncogenes, the two ubiquitously expressed isoforms of class IA phosphatidylinositol-3-kinases (PI3Ks), \(p110\alpha\) and \(p110\beta\), generate lipid second messengers at plasma membrane, which elic...
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| Language: | en_US |
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Harvard University
2013
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| Online Access: | http://dissertations.umi.com/gsas.harvard:10934 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11108476 |