Total Synthesis of Aflastatin A

Total Synthesis of Aflastatin A

The syntheses of aflastatin A and its C3-C48 degradation fragment are described. The syntheses feature several complex diastereoselective fragment couplings, including a C35-C36 anti-Felkin-selective boron-mediated oxygenated aldol reaction, a C15-C16 Felkin-selective trityl-catalyzed Mukaiyama aldo...

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Bibliographic Details
Main Author:	Beiger, Jason James
Other Authors:	Evans, David A.
Language:	en_US
Published:	Harvard University 2013
Subjects:	Organic chemistry aflastatin aldol reaction natural products stereochemistry structural revision total synthesis
Online Access:	http://dissertations.umi.com/gsas.harvard:11040 http://nrs.harvard.edu/urn-3:HUL.InstRepos:10974701

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