Total Synthesis of Aflastatin A

Total Synthesis of Aflastatin A

The syntheses of aflastatin A and its C3-C48 degradation fragment are described. The syntheses feature several complex diastereoselective fragment couplings, including a C35-C36 anti-Felkin-selective boron-mediated oxygenated aldol reaction, a C15-C16 Felkin-selective trityl-catalyzed Mukaiyama aldo...

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Bibliographic Details
Main Author: Beiger, Jason James
Other Authors: Evans, David A.
Language:en_US
Published: Harvard University 2013
Subjects:
Organic chemistry
aflastatin
aldol reaction
natural products
stereochemistry
structural revision
total synthesis
Online Access:http://dissertations.umi.com/gsas.harvard:11040
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10974701

Internet

http://dissertations.umi.com/gsas.harvard:11040
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10974701

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