Elucidating Mechanisms of IgH Class Switch Recombination Involving Switch Regions and Double Strand Break Joining

Elucidating Mechanisms of IgH Class Switch Recombination Involving Switch Regions and Double Strand Break Joining

During IgH class switch recombination (CSR) in mature B lymphocytes, activation-induced cytidine deaminase (AID) initiates DNA double strand breaks (DSBs) within switch (S) regions flanking different sets of the IgH locus (IgH) constant \((C_H)\) region exons. End-Joining of DSBs in the upstream don...

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Bibliographic Details
Main Author: Zhang, Tingting
Other Authors: Alt, Frederick W.
Language:en_US
Published: Harvard University 2013
Subjects:
53BP1
class switch recombination
double strand break repair
IgH
switch regions
immunology
Online Access:http://dissertations.umi.com/gsas.harvard:10047
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10336910

Internet

http://dissertations.umi.com/gsas.harvard:10047
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10336910

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