Identification of Host Factors Required for Anthrax Lethal Toxin Intoxication Using Chemical Genetic and RNAi Approaches
Bacterial toxins have co-opted host cell machinery in order to enter cells and exert their deleterious effects. Anthrax toxin is composed of the receptor binding protein protective antigen (PA), and the enzymatic subunits lethal factor (LF) and edema factor (EF), which form the binary toxin complexe...
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| Language: | en_US |
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Harvard University
2013
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| Online Access: | http://dissertations.umi.com/gsas.harvard:10066 http://nrs.harvard.edu/urn-3:HUL.InstRepos:10288463 |