The pH-sensing mechanism of antibody recycling by the neonatal Fc receptor revealed using free energy perturbation calculations

The immune system produces antibodies to recognize and provide protection against infection. The immunoglobulin G (IgG) antibody isotype is present at high serum concentrations and has a longer half-life than other isotypes due to the interaction between its fragment crystallizable (Fc) region with...

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Bibliographic Details
Main Author: Sampson, Jared Matthew
Language:English
Published: 2021
Subjects:
Online Access:https://doi.org/10.7916/d8-kt1q-rp07