Re-thinking the role of ribosomal proteins in the Mdm2-p53 axis
The Mdm2-p53 axis is an important pathway in cells that is frequently misregulated in cancer. Under basal conditions, Mdm2 suppresses p53 through multiple mechanisms. However, when stress is encountered, this suppression is lifted and p53 transactivates the expression of many target genes to effect...
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| Language: | English |
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2013
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| Online Access: | https://doi.org/10.7916/D8CN739X |