PTEN regulates glutamine flux to pyrimidine synthesis and sensitivity to dihydroorotate dehydrogenase inhibition
The importance of metabolism in tumor initiation and progression is becoming increasingly clear. Metabolic changes induced by oncogenic drivers of cancer contribute to tumor growth and are attractive targets for cancer treatment. Phosphatase and Tensin homolog deleted from chromosome ten (PTEN) is o...
| Main Author: | |
|---|---|
| Language: | English |
| Published: |
2017
|
| Subjects: | |
| Online Access: | https://doi.org/10.7916/D86114ZT |