A surface plasmon resonance assay to determine the effect of influenza neuraminidase mutations on its affinity with antiviral drugs.
The outbreak of pandemic influenza and its ability to spread rapidly makes it a severe threat to public health. Antiviral drugs such as oseltamivir (Roche’s Tamiflu™) and zanamivir (GlaxoSmithKline’s Relenza™) are neuraminidase (NA) inhibitors (NI), which bind more tightly to NA than its natural sub...
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| Language: | en |
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University of Canterbury. Chemical and Process Engineering
2014
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| Online Access: | http://hdl.handle.net/10092/9183 |